Cymbimicin A and B, two novel cyclophilin-binding structures isolated from actinomycetes.
نویسندگان
چکیده
Two novel metabolites, cymbimicins A and B, were isolated from the culture broth of a strain of Micromonospora sp. by screening for cyclophilin binding metabolites from actinomycete strains. Cymbimicin A binds to cyclophilin A with a high affinity six fold lower than to that of cyclosporin A. The binding affinity of cymbimicin B is about 100 times lower. The taxonomy of the producing strain, fermentation, isolation, physical and biological properties and structure elucidation are described.
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 50 11 شماره
صفحات -
تاریخ انتشار 1997